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Reference: Oligostilbenoids in Vitis vinifera L. Pinot Noir Grape Cane Extract- Isolation, Characterization, in vitro Antioxidant Capacity and Anti-proliferative Effect on Cancer Cells
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Abstract-

The following oligostilbenoids were isolated from extracts of Vitis vinifera L. Pinot Noir grape canes produced at a pilot-plant scale: (E)-ε-viniferin, (E)-resveratrol, (E)-piceatannol, ampelopsin A, vitisin B, pallidol, (E)-δ-viniferin, (E)-ω-viniferin, (E)-trans-cis-miyabenol C, isorhapontigenin, scirpusin A, and a new isomer named iso-scirpusin A. The antioxidant capacity of the isolated stilbenoids was studied by three different assays, and their 50% inhibition concentration (IC50) against cancer cells was determined by MTT reduction assay. Besides (E)-resveratrol, stilbenoids have outstanding antioxidant capacity in the ORAC-FL assay. The strongest antiproliferative effect was observed for (E)-piceatannol and ampelopsin A against the bladder cancer cell line J82. (E)-Piceatannol has inhibitory effect on human lung cancer SK-MES-1 cells. Moreover, the whole extract has antiproliferative effect on all tested cell lines. In conclusion, beside (E)-resveratrol, grape cane extract contains oligostilbenoids with potential health benefits. This underexploited viticultural residue has the potential to produce valuable phytochemicals or ingredients in functional foods.

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Link to paper-

https://www.sciencedirect.com/science/article/pii/S0308814618308434

https://doi.org/10.1016/j.foodchem.2018.05.050

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Guaranteed Excellence NDtech-   an individualized quality control screening technology for natural cork stoppers that delivers the world’s first natural cork with a non-detectable TCA guarantee*.   *releasable TCA content below the 0.5 ng/L quantification limit; analysis performed in accordance to ISO 20752.

Publication Details

Published: 2018
Publication: Food Chemistry
Issue: 2018 Online May 2018
Author: Saez V 2018
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