ADVANCED INTERACTION SEARCH

VitiSynth Full Entry

Reference: Inferring Gene Regulatory Networks from a Population of Yeast Segregants
Key Statements

Abstract-

Constructing gene regulatory networks is crucial to unraveling the genetic architecture of complex traits and to understanding the mechanisms of diseases. On the basis of gene expression and single nucleotide polymorphism data in the yeast, Saccharomyces cerevisiae, we constructed gene regulatory networks using a two-stage penalized least squares method. A large system of structural equations via optimal prediction of a set of surrogate variables was established at the first stage, followed by consistent selection of regulatory effects at the second stage. Using this approach, we identified subnetworks that were enriched in gene ontology categories, revealing directional regulatory mechanisms controlling these biological pathways. Our mapping and analysis of expression-based quantitative trait loci uncovered a known alteration of gene expression within a biological pathway that results in regulatory effects on companion pathway genes in the phosphocholine network. In addition, we identify nodes in these gene ontology-enriched subnetworks that are coordinately controlled by transcription factors driven by trans-acting expression quantitative trait loci. Altogether, the integration of documented transcription factor regulatory associations with subnetworks defined by a system of structural equations using quantitative trait loci data is an effective means to delineate the transcriptional control of biological pathways.

(highlighting by VitiSynth)

Link to paper-

https://www.nature.com/articles/s41598-018-37667-4


Partially indexed reference.

View Interactions

VitiSynth Review
Go Back

Vitisynth

Guaranteed Excellence NDtech-   an individualized quality control screening technology for natural cork stoppers that delivers the world’s first natural cork with a non-detectable TCA guarantee*.   *releasable TCA content below the 0.5 ng/L quantification limit; analysis performed in accordance to ISO 20752.

Publication Details

Published: 2019
Publication: Scientific Reports
Issue: 2019 9-1197
Author: Chen C 2019
Recommendation:

NOT SET

Related Video

None for this Entry

Related Audio

None for this Entry

Discuss this Entry

No related discussions available.

Join Discussion

Latest Discussions
Special Report

Date: 29th October 2015
Reference:Journal:Weed Technology:2015:Online October 2015:Devkota P 2015:Influence of Spray Solution Temperature and Holding Duration on Weed Control with Premixed Glyphosate and Dicamba Formulation

Pesticides in general are chemical products, therefore the quality of ...Read more

Date: 3rd February 2015
Polls:0009:Data standards:03 Malvidin-3-glucoside or Malvidin-3-O-glucoside or Malvidin 3-O-β-D-glucoside?

Malvidin-3-glucoside or Malvidin-3-O-glucoside or Malvidin 3-O-β-D-gl...Read more

Date: 26th January 2015
Admin Synth:Guides:Data standards:Wine industry research papers (draft standard)

I think we should be developing a standard for wine industry research ...Read more

Testimonials.. Read more

test